| CatalogCode: | NB100-64611 |
| ProductName: | EGF R Antibody |
| Product Description: | Mouse Monoclonal anti-EGF R (F4), conjugated to FITC |
| Clone: | F4 |
| Clonality: | Monoclonal |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 1 ml of Serum liquid |
| Uses: | This antibody is useful for Immunohistochemistry-Frozen |
| Background: | Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein. Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Whole Antisera |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr |
| SpeciesSummary: | Hu |
| ProteinTarget: | EGF R |
| PackageSize: | 1 ml |
| Conjugate: | FITC |
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