| CatalogCode: | NB100-64067 |
| ProductName: | CD86 Antibody |
| Product Description: | Mouse Monoclonal anti-CD86 (OX-48) |
| Clone: | OX-48 |
| Clonality: | Monoclonal |
| Specificity: | NB100-64067 recognises rat CD86 (B7-2), a transmembrane protein which has been identified as a ligand for both CD28 and CD152. CD86 is predominantly expressed on antigen presenting cells, and expression may also be induced on B-cells by activation. |
| CrossReactivity: | Rat. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Mouse IgG. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell Membrane; single pass type I membrane protein. |
| Background: | CD86, also known as B72, is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell costimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Rt |
| ALTnames: | anti-FUN1 antibody, anti-Activation B7 2 antigen antibody, anti-Activation B72 antigen antibody, anti-B lymphocyte activation antigen B7 2 antibody, anti-B lymphocyte activation antigen B72 antibody, anti-B7 2 antibody, anti-B7 2 antigen antibody, anti-B70 antibody, anti-BU63 antibody, anti-CD 86 antibody, anti-CD28 antigen ligand 2 antibody, anti-CD28LG2 antibody, anti-CD86 antigen antibody, anti-CD86 molecule antibody, anti-CTLA 4 counter receptor B7 2 antibody, anti-CTLA 4 counter receptor B7.2 antibody, anti-CTLA4 counter receptor B72 antibody, anti-FUN 1 antibody, anti-LAB72 antibody, anti-MGC34413 antibody, anti-T lymphocyte activation antigen CD86 antibody |
| ProteinTarget: | CD86 |
| PackageSize: | 0.25 mg |
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