| CatalogCode: | NB100-63968 |
| ProductName: | CD62L Antibody |
| Product Description: | Mouse Monoclonal anti-CD62L (OX-85) |
| Clone: | OX-85 |
| Clonality: | Monoclonal |
| Specificity: | NB100-63968 recognises rat L-selectin (CD62L). In rats CD62L is expressed by a subset of thymocytes, predominantly single positive CD4 or CD8 cells. Expression of rat CD62L is weak, and sensitive detection systems (e.g.. 3 layer biotin - streptavidin techniques) are recommended on some tissues. |
| CrossReactivity: | Rat. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. Human CD62L (L Selectin) is comprised of an aminoterminal C type lectin binding domain, an epidermal growth factor like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells. It is expressed on bone marrow myeloid progenitor cells, erythroid precursor cells and some thymocytes. It is preferentially localized to the tips of lymphocytes and polymorphonuclear cells microvilli. Bioactive soluble L Selectin derived from lymphocytes and neutrophils is present in normal and pathological biological fluids. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline pH7.4 |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Rt |
| ALTnames: | anti-gp90 MEL antibody, anti-hLHRc antibody, anti-L Selectin antibody, anti-LAM1 antibody, anti-LECAM1 antibody, anti-Leukocyte adhesion molecule 1 antibody, anti-Leukocyte surface antigen Leu8 antibody, anti-LNHR antibody, anti-LSEL antibody, anti-LYAM1 antibody, anti-Lymph node homing receptor antibody, anti-Lymphocyte adhesion molecule 1 antibody, anti-PLNHR antibody, anti-Selectin L antibody, anti-SELL antibody, anti-TQ1 antibody |
| ProteinTarget: | CD62L |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Seddon, B. et al. (1996) CD4+ CD8- thymocytes that express L-selectin protect rats from diabetes upon adoptive transfer. Eur. J. Immunol. 26: 2702-2708. |
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