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| Catalog Code: | NB100-63912 |
| Product Name: | CD5 Antibody |
| Product Description: | Mouse Monoclonal anti-CD5 (OX-19), conjugated to Biotin |
| Clone: | OX-19 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Cross Reactivity: | Rat. Not yet tested in other species. |
| Packaging: | 100 tests of Purified IgG conjugated to Biotin. Liquid. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | In humans, CD5 is a 67kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature T lymphocytes, on most thymocytes and on many T cell leukemias and lymphomas. It reacts with a subpopulation of activated B cells. CD5/Lyt1 antigen is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B cell antigen CD72. The frequency of CD5+ B cells exhibits strain dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B1 cells. Binding of CD5 on the T cell surface can augment alloantigen or mitogen induced lymphocyte proliferation and induces increased cytosolic free calcium, IL2 secretion, and IL2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T cell and B cell receptors. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | IgG Purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Rt |
| Package Size: | 100 tests |
| Preservative: | Sodium Azide |
| Conjugate: | Biotin |
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