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| Catalog Code: | NB100-63883 |
| Product Name: | CD49d Antibody |
| Product Description: | Mouse Monoclonal anti-CD49d (44H6), conjugated to Biotin |
| Clone: | 44H6 |
| Clonality: | Monoclonal |
| ListPrice: | 315 |
| Cross Reactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg of Purified IgG conjugated to Biotin. Liquid. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | IgG Purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Package Size: | 0.1 mg |
| Preservative: | Sodium Azide |
| Conjugate: | Biotin |
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