| CatalogCode: | NB100-63834 |
| ProductName: | CD45.1 Antibody |
| Product Description: | Rat Monoclonal anti-CD45.1 (NDS 58) |
| Clone: | NDS 58 |
| Clonality: | Monoclonal |
| Immunogen: | Thymocytes from LEW rat |
| Specificity: | NB100-63834 recognises rat CD45.1 (RT7.1), expressed by rat strains including AO, BN, DA, LEW and PVG.The antibody does not react with the RT7.2 alloantigen. |
| CrossReactivity: | Rat. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein. |
| Background: | CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline pH7.2 |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Rt |
| ALTnames: | anti-GP180 antibody, anti-LCA antibody, anti-Leukocyte common antigen precursor antibody, anti-RT7.1 antibody |
| ProteinTarget: | CD45.1 |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Newton, M.R. et al. (1986) A monoclonal alloantibody detecting a polymorphism of the rat leucocyte common (LC) antigen. J. Immunogenet. 13: 41-50. 2. Butcher, G.W. (1987) A list of monoclonal antibodies specific for alloantigens of the rat. J. Immunogenet. 14: 163-176. 3. Todd, D. J. et al. (2004) Deficiencies in gut NK cell number and function precede diabetes onset in BB rats. J. Immunol. 9: 5356-5362. |
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