| CatalogCode: | | NB100-63738 |
| ProductName: | | CD38 Antibody |
| Product Description: | | Mouse Monoclonal anti-CD38 (AT13/5), conjugated to Biotin |
| Clone: | | AT13/5 |
| Clonality: | | Monoclonal |
| Specificity: | | NB100-63738 recognises the human CD38 cell surface antigen, a 45kD glycoprotein. CD38 is expressed by plasma cells, monocytes, early lymphoid cells and activated T cells.CD38 is widely used to study the processes of T and B cell differentiation and activation. Recently CD38 has been shown to possess ADP-ribosyl cyclase activity. |
| CrossReactivity: | | Human. Not yet tested in other species. |
| Packaging: | | 0.1 mg protein A purified Mouse ascites. |
| Uses: | | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | | Membrane; single pass type II membrane protein. |
| Background: | | CD38 (T10) is a single chain 42 to 46 kDa type II integral transmembrane glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. It is expressed by murine, but not human, hematopoietic progenitors. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor. In mice, CD38 is expressed by follicular B cells, is down regulated on germinal centre B cells, and is not expressed by mature plasma cells. Murine CD38 is also expressed by all Mac1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone marrow derived macrophages. This pattern of expression contrasts strikingly with that seen in the human. Monoclonal antibodies to CD38 have been shown to be useful in subtyping of lymphomas and leukemias, inhibition of B lymphopoiesis, detection of plasma cells, protection of B cells from apoptosis, and as a marker for activated B and T cell proliferation. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | | protein A purified |
| Isotype: | | IgG1 |
| Host_Name: | | Mouse |
| Buffer: | | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | | 295 |
| AppSummary: | | FACS |
| SpeciesSummary: | | Hu |
| ALTnames: | | Anti-Acute lymphoblastic leukemia cells antigen CD38 antibody; Anti-ADP ribosyl cyclase 1 antibody; Anti-ADP ribosyl cyclase antibody; Anti-CADPr hydrolase 1 antibody; Anti-CD 38 antibody; Anti-CD38 antigen antibody; Anti-CD38 molecule antibody; Anti-Cyclic ADP ribose hydrolase antibody; Anti-Cyclic ADP ribose hydrolase 1 antibody; Anti-Ecto nicotinamide adenine dinucleotide glycohydrolase antibody; Anti-I19 (mouse) antibody; Anti-Lymphocyte differentiation antigen CD38 antibody; Anti-NIMR5 antigen (mouse) antibody; Anti-p45 antibody; Anti-T10 antibody |
| ProteinTarget: | | CD38 |
| PackageSize: | | 0.1 mg |
| Conjugate: | | Biotin |
| GeneralRef: | | 1. Malavasi, F. et al. (1994) Human CD38: a glycoprotein in search of a function. Immunol. Today. 15: 95-97. 2. Ellis, J.H. et al. (1995) Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma. J. Immunol. 155: 925-937. |
| more information: | | company product webpage |