| CatalogCode: | NB100-63731 |
| ProductName: | CD34 CLASS II Antibody |
| Product Description: | Mouse Monoclonal anti-CD34 CLASS II (QBEND/10), conjugated to FITC |
| Clone: | QBEND/10 |
| Clonality: | Monoclonal |
| Immunogen: | Human endothelial cell membrane vesicles |
| Specificity: | NB100-63731 recognises the human CD34 cell surface antigen, a 110kD cell surface glycoprotein expressed by haematopoietic stem cells, and by capillary endothelial cells.This antibody has been shown to recognises a class 2 epitope of CD34. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 100 tests Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ProteinTarget: | CD34 CLASS II (NOT FOR SALE IN USA) |
| PackageSize: | 100 tests |
| Conjugate: | FITC |
| GeneralRef: | 1. Fina, L. et al. (1990) Expression of the CD34 gene in vascular endothelial cells. Blood 95: 2417-2426. 2. Sopper, S. et al. (1997) Lympocyte subsets and expression of differentiation markers in blood and lymphoid organs of Rhesus monkey. Cytometry 29: 351-362. 3. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49: 97-110. |
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