| CatalogCode: | NB100-63698 |
| ProductName: | CD305 Antibody |
| Product Description: | Mouse Monoclonal anti-CD305 (NKTA255), conjugated to Biotin |
| Clone: | NKTA255 |
| Clonality: | Monoclonal |
| Immunogen: | NK cells lines B12.100 and AM.25 |
| Specificity: | NB100-63698 recognises human leukocyte-associated Ig-like receptor-1 (LAIR-1), a 40kD cell surface molecule that functions as an inhibitory receptor on natural killer cells, monocytes and T cells. LAIR-1, otherwise known as CD305, is also expressed by other haematopoietic cells including B cells, but is not expressed by non-haematopoietic, platelets or erythrocytes.Clone NKTA255 is reported to inhibit NK cell triggering via CD16 molecules (1). |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell Membrane |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-5133400O11Rik antibody; Anti-D7Bwg0421e antibody; Anti-LAIR 1 antibody; Anti-LAIR1 protein antibody; Anti-Leukocyte associated Ig like receptor 1 antibody; Anti-Leukocyte associated immunoglobulin like receptor 1 antibody |
| ProteinTarget: | CD305 |
| PackageSize: | 0.1 mg |
| Conjugate: | Biotin |
| GeneralRef: | 1. Poggi, A. et al. (1995) p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur. J. Immunol. 25: 369 - 376. 2. Zocchi, M. R. et al. (2001) Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur. J. Immunol. 31: 3667 - 3675. 3. Poggi, A. et al. (2000) Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents nuclear translocation in human myeloid leukemias. Eur. J. Immunol. 30: 2751 - 2758. |
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