| CatalogCode: | NB100-63692 |
| ProductName: | CD30 Antibody |
| Product Description: | Mouse Monoclonal anti-CD30 (CON6D/B5), conjugated to PE |
| Clone: | CON6D/B5 |
| Clonality: | Monoclonal |
| Immunogen: | Hodgkin's lymphoma cell line L428 |
| Specificity: | NB100-63692 recognises the human CD30 cell surface antigen, a 120kD glycoprotein. CD30 is expressed on a subset of activated human T lymphocytes, and by a few extrafollicular T and B cell blasts in normal lymph nodes. CD30 was originally identified as a molecule expressed on Hodgkin and Reed Sternberg cells in Hodgkin's disease but has subsequently been detected on certain non-Hodgkin's malignancies as well as some virally transformed cells. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 100 tests protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein (long isoform); cytoplasmic (short isoform). |
| Background: | CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkin's and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation, and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells, CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas), virus-infected T and B cells, and on normal T and B cells after activation. In T cells, CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that coexpress CD45RO and the IL4 receptor. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CD 30 antibody; Anti-CD153 antibody; Anti-CD30 antigen antibody; Anti-CD30L receptor antibody; Anti-Cytokine receptor CD30 antibody; Anti-D1S166E antibody; Anti-KI 1 antibody; Anti-Ki 1 antigen antibody; Anti-KI1 antibody; Anti-Lymphocyte activation antigen CD30 antibody; Anti-TNFRSF8 antibody; Anti-Tumor Necrosis Factor Receptor Superfamily Member 8 antibody |
| ProteinTarget: | CD30 |
| PackageSize: | 100 tests |
| Conjugate: | PE |