| CatalogCode: | NB100-63667 |
| ProductName: | CD29 Antibody |
| Product Description: | Hamster Monoclonal anti-CD29 (HM beta 1-1), conjugated to FITC |
| Clone: | HM beta 1-1 |
| Clonality: | Monoclonal |
| Immunogen: | Purified mouse VLA-4 antigen |
| Specificity: | NB100-63667 recognises the murine integrin beta 1 subunit (CD29), a 110KD cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. CD29 forms non-covalent bonds with the integrin alpha subunits, including CD51 and CD49a-f, to form heterodimers. The ligands for these heterodimers include collagen, fibronectin, laminin and vascular adhesion molecule-1. In the immune system beta 1 integrins play an important role in cell adhesion, migration, activation and differentiation.Clone HM beta 1.1 is reported to inhibit beta 1 integrin mediated adhesion (1). |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.5 mg protein G purified Hamster ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type 1 membrane protein |
| Background: | Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host_Name: | Hamster |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 325 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-beta 1 subunit antibody; Anti-CD29 antigen antibody; Anti-Fibrinogen Receptor beta subunit antibody; Anti-FNRB antibody; Anti-GPIIA antibody; Anti-integrin beta 1 (fibronectin receptor beta polypeptide antigen CD29 includes MDF2 MSK12) antibody; Anti-Integrin VLA 4 subunit beta antibody; Anti-ITGB 1 antibody; Anti-ITGB1 antibody; Anti-MDF2 antibody; Anti-MSK12 antibody; Anti-Very Late Activation Protein beta Polypeptide antibody; Anti-VLAB antibody; Anti-VLAbeta antibody |
| ProteinTarget: | CD29 |
| PackageSize: | 0.5 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb. Int. Immunol. 7: 835-842. |
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