| CatalogCode: | NB100-63638 |
| ProductName: | CD25 Antibody |
| Product Description: | Rat Monoclonal anti-CD25 (YTH906.9HL) |
| Clone: | YTH906.9HL |
| Clonality: | Monoclonal |
| Immunogen: | Activated human T lymphocytes |
| Specificity: | NB100-63638 recognises the low affinity IL-2 receptor (CD25), expressed by activated T lymphocytes, that has a molecular weight of 55kD. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 200 tests Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | The IL2 receptor (IL2R) exists in three alternative forms made up from the individual components of CD25, CD122, and CD132. CD25 represents the low affinity alpha chain of the IL2R, a type I transmembrane glycoprotein containing two CCP domains. It is rich in O linked carbohydrates and has a short cytoplasmic tail. CD25 is expressed on activated T cells, B cells, NK cells and monocytes of all mouse strains tested. It is transiently expressed at a low level during B cell development in bone marrow on the CD45R/B220 low TdT- sIg- pre-B II and CD45R/B220low TdT- sIgM+sIgD- immature B cells, but not on the CD45R/B220 low TdT+ sIg- pro-B/pre B I stage nor on CD45R/B220high TdT- sIgM+sIgD+ mature B cells. CD25 is expressed at a higher level during very early T cell development in fetal and adult thymus. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG2b |
| Host_Name: | Rat |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-IL-2R ALPHA CHAIN antibody |
| ProteinTarget: | CD25 |
| PackageSize: | 200 tests |
| GeneralRef: | 1. Katz, B. et al. (2003) Targeting membrane-localized focal adhesion kinase to focal adhesions. J. Biol. Chem. 278:29115-29120. |
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