| CatalogCode: | NB100-63623 |
| ProductName: | CD247 Antibody |
| Product Description: | Mouse Monoclonal anti-CD247 (G3), conjugated to FITC |
| Clone: | G3 |
| Clonality: | Monoclonal |
| Immunogen: | 113 amino acid synthetic peptide corresponding to the cytoplasmic domain of murine zeta TCR subunit. |
| Specificity: | The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma/delta/eta and zeta subunits, all of which are required for efficient surface expression. T cell activation through the TCR induces cellular differentiation and/or proliferation and the production of lymphokines and cytokines. Both the CD3 and TCR zeta subunits are proposed to be responsible for the intracellular signal transduction events.A novel monoclonal antibody, named G3, has been developed that is specific for the TCR zeta chain subunit (CD247). The antibody is capable of precipitating both non-phosphorylated and tyrosine phosphorylated TCR zeta chain and may be used to detect TCR zeta expressing cells using flow cytometry on permeabilised cells. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell Membrane |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.2, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CD3 ZETA antibody; Anti-CD3H antibody; Anti-CD3Q antibody; Anti-CD3Z antibody; Anti-CD3Z antigen zeta polypeptide antibody; Anti-T cell receptor T3 zeta chain antibody; Anti-T cell receptor zeta chain antibody; Anti-T cell surface glycoprotein CD3 zeta chain antibody; Anti-T3Z antibody; Anti-TCRZ antibody; Anti-TiT3 complex antibody |
| ProteinTarget: | CD247 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. van Oers, N.S.C. et al. (1994) Production and characterisation of monoclonal antibodies specific for the murine T cell receptor zeta chain. J. Immunol. Methods 170: 261-268. 2. Anderson, P. (1995) mAb reative with lymphocyte restricted intracellular antigens in Leucocyte Typing V p325, Oxford University Press. |
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