| CatalogCode: | NB100-63604 |
| ProductName: | CD226 Antibody |
| Product Description: | Mouse Monoclonal anti-CD226 (DX11), conjugated to PE |
| Clone: | DX11 |
| Clonality: | Monoclonal |
| Immunogen: | Human cytotoxic T lymphocyte clone |
| Specificity: | NB100-63604 recognises human CD226, a 65kD glycoprotein, also known as DNAM1 (DNAX accessory molecule-1). CD226 is broadly expressed on T-cells, NK cells, platelets, monocytes and a subset of B cells. CD226 is also expressed by a subset of CD3 positive thymocytes.Clone DX11 is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells (3). |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 100 tests protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1.0% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-DNAM-1 antibody |
| ProteinTarget: | CD226 |
| PackageSize: | 100 tests |
| Conjugate: | PE |
| GeneralRef: | 1. Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity. 4: 573 - 581. 2. Shibuya, A. et al. (1998) Protein kinase C is involved in the regulation of both signaling and adhesion mediated by DNAX Accessory molecule-1 receptor. J. Immunol. 161. 1671 - 1676. 3. Kojima, H. et al. (2003) CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J. Biol. Chem. 278 (38): 36748 - 36753. |
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