| CatalogCode: | NB100-63601 |
| ProductName: | CD223 Antibody |
| Product Description: | Rat Monoclonal anti-CD223 (C9B7W) |
| Clone: | C9B7W |
| Clonality: | Monoclonal |
| Immunogen: | Murine CD223 Ig fusion protein |
| Specificity: | NB100-63601 recognises murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223.Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion.Clone C9B7W recognises an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II (1). |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4 |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-LAG-3 antibody |
| ProteinTarget: | CD223 |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur. J. Immunol. 32:2255 - 2263. 2. Workman, C.J. et al. (2005) Negative Regulation of T cell Homeostasis by Lymphocyte Activation gene-3 (CD223). J. Immunol.174:688 - 695 |
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