| CatalogCode: | NB100-63598 |
| ProductName: | CD221 Antibody |
| Product Description: | Mouse Monoclonal anti-CD221 (1H7), conjugated to PE |
| Clone: | 1H7 |
| Clonality: | Monoclonal |
| Specificity: | NB100-63598 recognises human CD221, a 155kD receptor tyrosine kinase, also known as Insulin-like growth factor I receptor (IGF-I Receptor). CD221 is composed of two extracellular alpha-subunits and two transmembrane beta-subunits. Clone 1H7 recognises an epitope in the alpha subunits of CD221, demonstrated by Western blotting (1).CD221 is expressed in a range of tissues, including kidney, liver, placenta, mammary gland, brain, ovary and skin.The ligands for CD221 include IGF-I and IGF-II, which bind to CD221 and activate tyrosine kinase activity, resulting in phosphorylation of several intracellular signalling proteins. Clone 1H7 is reported to partically block binding of IGF-I and IGF-II to CD221 (1). |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 100 tests protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-IGF-1 RECEPTOR antibody |
| ProteinTarget: | CD221 |
| PackageSize: | 100 tests |
| Conjugate: | PE |
| GeneralRef: | 1. Li, S.L. et al. (1993) Two new monoclonal antibodies against the alpha subunit of the human insulin-like growth factor-I receptor. Biochem. Biophys. Res. Commun. 196:92-98. |