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| Catalog Code: | NB100-63594 |
| Product Name: | CD22 Antibody |
| Product Description: | Rat Monoclonal anti-CD22 (OX-96), conjugated to FITC |
| Clone: | OX-96 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.1 mg/ml |
| Specificity: | NB100-63594 recognises domain 1 of the murine cell surface glycoprotein CD22, which is a member of the sialoadhesin family. CD22 is expressed on a subpopulation of mature B-lymphocytes and may modulate signalling through the B-cell antigen receptor. Clone OX96 does not block CD22 function. |
| Cross Reactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | CD22 is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. It is expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. There are two different isoforms of CD22. It exists predominantly as a monomer of the beta isoform but can also be found as a heterodimer composed of the beta isoform and a second, shorter isoform (CD22 alpha). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin Serum |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | Anti-Lyb-8 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Conjugate: | FITC |
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more information: | company product webpage |