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| Catalog Code: | NB100-63586 |
| Product Name: | CD22 Antibody |
| Product Description: | Mouse Monoclonal anti-CD22 (Bu59) |
| Clone: | Bu59 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 1.0mg/ml |
| Specificity: | NB100-63586 recognises human CD22, a 130/140kD cell surface glycoprotein which is expressed by cells of B-lymphocyte lineage. CD22 is differentially expressed during B cell maturation. Initially, CD22 is expressed in the cytoplasm of pro-B and pre-B cells and then on the cell surface of mature B cells. CD22 expression is lost upon terminal differentiation to plasma cells. CD22 functions as an adhesion receptor, for leucocytes and erythrocytes, and a signalling molecule which may play a role in B-cell activation. |
| Cross Reactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | CD22 is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. It is expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. There are two different isoforms of CD22. It exists predominantly as a monomer of the beta isoform but can also be found as a heterodimer composed of the beta isoform and a second, shorter isoform (CD22 alpha). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4 |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | Anti-BL-CAM antibody |
| Package Size: | 0.2 mg |
| Preservative: | 0.09% Sodium Azide |
| General References: | 1. Garland Publishing, Inc. (1998) Leucocyte Typing VI. p 143 - 144 |
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