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| Catalog Code: | NB100-63564 |
| Product Name: | CD200R Antibody |
| Product Description: | Rat Monoclonal anti-CD200R (OX-110), conjugated to Biotin |
| Clone: | OX-110 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | Fusion protein mCD200RCD4d3+4 |
| Specificity: | NB100-63564 recognises mouse CD200R, a cell surface glycoprotein (also known as OX2R), In mouse CD200R is expressed primarily by peripheral blood monocytes and neutrophils but also by other leucocytes including T-lymphocytes and mast cells (1) . Studies suggest that CD200-CD200R interaction may be involved in the control of myeloid cellular function. |
| Cross Reactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Isoform 1 and isoform 4: Cell membrane; single pass type I membrane protein. Isoform 2 and isoform 3: Secreted protein. |
| Background: | CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. It is a monomorphic determinant expressed on thymocytes, brain, follicular dendritic cells in all lymphoid organs, endothelium and at low levels on some smooth muscle and B lymphocytes. Recent studies have suggested that the CD200 - CD200 ligand system is of importance in the control of macrophage and granulocyte activation. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | Anti-OX2R antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Conjugate: | Biotin |
| General References: | 1. Wright, G.J. et al. (2003) Characterization of the CD200 Receptor family in mice and humans and their interactions with CD200. J. Immunol. 171:3034-3046. |
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