| CatalogCode: | NB100-63533 |
| ProductName: | CD2 Antibody |
| Product Description: | Mouse Monoclonal anti-CD2 (LT2), conjugated to FITC |
| Clone: | LT2 |
| Clonality: | Monoclonal |
| Immunogen: | Normal human peripheral blood lymphocytes. |
| Specificity: | NB100-63533 is a single chain transmembrane glycoprotein of 50kD, expressed by T cells, NK cells and thymocytes.CD2 is a receptor for CD58 (LFA-3), and is important in mediating the interaction between T cells and target cells or antigen presenting cells. MCA1194 inhibits NK cell mediated cytotoxicity, and ConA and PHA mediated blast transformation. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein. |
| Background: | CD2 is a surface antigen of the human T lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. CD2 interacts with lymphocyte function associated antigen (LFA3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 is implicated in the triggering of T cells, the cytoplasmic domain is implicated in the signaling function. It is useful for the identification of lymphomas and leukaemias of T cell origin. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG2b |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CD 2 antibody; Anti-CD2 antigen (p50) sheep red blood cell receptor antibody; Anti-CD2 antigen antibody; Anti-CD2 molecule antibody; Anti-Erythrocyte receptor antibody; Anti-LFA 2 antibody; Anti-LFA 3 receptor antibody; Anti-LFA2 antibody; Anti-LFA3 receptor antibody; Anti-Lymphocyte function antigen 2 antibody; Anti-p50 antibody; Anti-Rosette receptor antibody; Anti-Sheep erythrocyte receptor antibody; Anti-Sheep red blood cell receptor antibody; Anti-SRBC antibody; Anti-T cell surface antigen CD2 antibody; Anti-T cell surface antigen T11/Leu 5 antibody; Anti-T11 antibody |
| ProteinTarget: | CD2 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. Moingeon, P. et al. (1989) The structural biology of CD2. Immunol. Rev. 111: 111-144. 2. Beyers, A.D. et al. (1989) Activation of T lymphocytes via monoclonal antibodies against rat cell surface antigens with particular reference to CD2 antigen. Immunol. Rev. 111: 59-77. |
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