| CatalogCode: | NB100-63502 |
| ProductName: | CD18 Antibody |
| Product Description: | Rat Monoclonal anti-CD18 (C71/16), conjugated to PE |
| Clone: | C71/16 |
| Clonality: | Monoclonal |
| Immunogen: | Cell membrane glycoproteins derived from BW5147 cells |
| Specificity: | NB100-63502 recognises the murine CD18 cell surface glycoprotein, a 95kD molecule also known as the beta2 integrin. This molecule may form heterodimers with the alphaM, alphaL or alphaX integrins. CD18 is expressed by the majority of leucocytes. |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.5 ml IgG purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG2a |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 0.5% Bovine Serum Albumin |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-Beta 2 (antigen CD18 (p95) antibody; Anti-CD 18 antibody; Anti-CD18 antigen antibody; Anti-Cell surface adhesion glycoproteins LFA 1/CR3/p150 95 subunit beta antibody; Anti-Cell surface adhesion glycoproteins LFA 1/CR3/p15095 beta subunit antibody; Anti-Complement component 3 receptor 3 and 4 subunit antibody; Anti-Complement receptor C3 beta subunit antibody; Anti-Integrin beta 2 antibody; Anti-Integrin beta chain beta 2 antibody; Anti-ITGB 2 antibody; Anti-ITGB2 antibody; Anti-LAD antibody; Anti-LCAMB antibody; Anti-Leukocyte Cell Adhesion Molecule CD18 antibody; Anti-LFA 1 antibody; Anti-LFA1 antibody; Anti-Lymphocyte function associated antigen 1 antibody; Anti-MAC 1 antibody; Anti-MAC1 antibody; Anti-Macrophage antigen 1 (mac1) beta subunit antibody; Anti-MF17 antibody; Anti-MFI7 antibody |
| ProteinTarget: | CD18 |
| PackageSize: | 0.5 ml |
| Conjugate: | PE |
| GeneralRef: | 1. Trowbridge, I.S. and Omary, M.B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen MAC-1. J. Exp. Med. 154: 1517-1524. 2. Springer, T. et al. (1982) LFA-1 homologue associated with complement receptor function. Immunol. Rev. 68: 171-195. 3. Larson, R.S. and Springer, T.A. (1990) Structure and function of leukocyte integrins. Immunol. Rev. 114: 181-217. |