| CatalogCode: | NB100-63483 |
| ProductName: | CD161 Antibody |
| Product Description: | Mouse Monoclonal anti-CD161 (B199.2), conjugated to FITC |
| Clone: | B199.2 |
| Clonality: | Monoclonal |
| Specificity: | NB100-63483 recognises the human CD161 cell surface antigen, expressed by almost all NK cells and with a small subset of CD3+ve T cells.CD161 is a homodimeric cell surface protein, comprising two chains of 40-44kD.Clone B199.2 recognises a similar epitope to the DX9 monoclonal antibody. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell Membrane |
| Background: | Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 (CD161) protein contains an extracellular domain with several motifs characteristic of C type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. In mouse the NKRP1 family has three members, NKRP1A, B and C, whilst in human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, b and c. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CLEC5B antibody; Anti-Killer Cell Lectin like Receptor Subfamily B Member 1 antibody; Anti-KLRB1 antibody; Anti-NKR antibody; Anti-NKRP1A antibody |
| ProteinTarget: | CD161 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. Bennett, I.M. et al. (1996) Definition of natural killer NKR-PIA+/CD56-/CD16- functionally immature human NK cell subset that differentiates in vitro in the presence of interleukin 12. J. Exp. Med. 184: 1845-1856. 2. Azzoni, L. et al. (1998) Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells. J. Immunol. 161: 3493-3500. |
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