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| Catalog Code: | NB100-63475 |
| Product Name: | CD16/CD32 Antibody |
| Product Description: | Rat Monoclonal anti-CD16/CD32 (FCR4G8), conjugated to Biotin |
| Clone: | FCR4G8 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | PU5 1.8 IOE7 Balb/c mouse cell line. |
| Specificity: | NB100-63475 recognises an epitope expressed by the murine low affinity Fc receptors, Fc gamma III (CD16) and Fc gamma II (CD32). In the mouse only the transmembrane form of CD16 is reported to exist, which is expressed on macrophages, NK cells, granulocytes, myeloid precursors, and subpopulations of T lymphocytes. CD32 is primarily expressed on cells of the myeloid lineage and also on mature B lymphocytes. |
| Cross Reactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | CD32: Type I membrane protein. CD16: Attached to the membrane by a GPI anchor. Exists also as a soluble receptor, produced by a proteolytic cleavage. |
| Background: | The lymphocyte Fc gamma receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fc gamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying Fc gamma R+ cells, monoclonal antibodies to the Fc gamma II/III receptor have been used to block Fc receptor binding of IgG, Fc mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc gamma R for parasitic invasion. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | Anti-CD 32 antibody; Anti-CD16a antibody; Anti-CD16b antibody; Anti-CD16b antigen antibody; Anti-CD32 antigen antibody; Anti-CD32A antibody; Anti-CD32B antibody; Anti-CDw32 antibody; Anti-Fc fragment of IgG low affinity II receptor antibody; Anti-Fc fragment of IgG low affinity IIa receptor antibody; Anti-Fc fragment of IgG low affinity IIb receptor antibody; Anti-Fc fragment of IgG low affinity III receptor antibody; Anti-Fc fragment of IgG low affinity IIIa receptor antibody; Anti-Fc fragment of IgG low affinity IIIb receptor antibody; Anti-Fc gamma II/III Receptors antibody; Anti-Fc gamma receptor antibody; Anti-Fc gamma receptor III A antibody; Anti-Fc gamma receptor IIIb antibody; Anti-Fc gamma RII a antibody; Anti-Fc gamma RII b antibody; Anti-Fc gamma RII c antibody; Anti-Fc gamma RIIa antibody; Anti-Fc gamma RIIb antibody; Anti-Fc gamma RIIc antibody; Anti-Fc gamma RIII alpha antibody; Anti-Fc gamma RIII antibody; Anti-Fc gamma RIII beta antibody; Anti-Fc gamma RIIIa antibody; Anti-Fc gamma RIIIb antibody; Anti-FCG2 antibody; Anti-FCG3 antibody; Anti-FcgammaRIIIA antibody; Anti-FcGR antibody; Anti-FCGR2 antibody; Anti-FCGR2A antibody; Anti-FCGR2A1 antibody; Anti-FCGR2B antibody; Anti-FCGR3 antibody; Anti-FCGR3A antibody; Anti-FCGR3B antibody; Anti-FcR 10 antibody; Anti-FcRII a antibody; Anti-FcRII b antibody; Anti-FcRII c antibody; Anti-FcRIII antibody; Anti-FcRIIIa antibody; Anti-Fcy II/III Receptors antibody; Anti-IGFR2 antibody; Anti-IGFR3 antibody; Anti-IgG Fc receptor II a antibody; Anti-IgG Fc receptor II b antibody; Anti-IgG Fc receptor II c antibody; Anti-IgG Fc receptor III 1 antibody; Anti-IgG Fc receptor III 2 antibody; Anti-Low affinity immunoglobulin gamma Fc region receptor II a antibody; Anti-Low affinity immunoglobulin gamma Fc region receptor II b antibody; Anti-Low affinity immunoglobulin gamma Fc region receptor II c antibody; Anti-Low affinity immunoglobulin gamma Fc region receptor III A antibody; Anti-Low affinity immunoglobulin gamma Fc region receptor III B antibody; Anti-MGC23887 antibody; Anti-MGC30032 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Conjugate: | Biotin |
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more information: | company product webpage |