| CatalogCode: | NB100-63472 |
| ProductName: | CD16 Antibody |
| Product Description: | Mouse Monoclonal anti-CD16 (LNK16), conjugated to FITC |
| Clone: | LNK16 |
| Clonality: | Monoclonal |
| Immunogen: | Normal human peripheral blood granulocytes |
| Specificity: | NB100-63472 recognises CD16, a 50-65kD cell surface molecule which exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes.CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell membrane; single pass type I membrane protein (potential). Secreted protein. Exists also as a soluble receptor. |
| Background: | The lymphocyte Fc gamma receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fc gamma type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying Fc gamma R+ cells, monoclonal antibodies to the Fc gamma II/III receptor have been used to block Fc receptor binding of IgG, Fc mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on Fc gamma R for parasitic invasion. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CD 16a antibody; Anti-CD16A antibody; Anti-CD16a antigen antibody; Anti-Fc fragment of IgG antibody; Anti-Fc gamma R3 antibody; Anti-Fc gamma RIII alpha antibody; Anti-Fc gamma RIII antibody; Anti-Fc gamma RIIIa antibody; Anti-Fc of IgG antibody; Anti-FCG 3 antibody; Anti-FCG3 antibody; Anti-FCGR 3 antibody; Anti-FCGR 3A antibody; Anti-FCGR3 antibody; Anti-FCGR3A antibody; Anti-FCGR3A protein antibody; Anti-FcR 10 antibody; Anti-FcR10 antibody; Anti-FcRIII antibody; Anti-FcRIIIa antibody; Anti-IGFR 3 antibody; Anti-IGFR3 antibody; Anti-IgG Fc receptor III 2 antibody; Anti-Low affinity IIIa receptor antibody; Anti-Low affinity immunoglobulin gamma Fc region receptor III A antibody |
| ProteinTarget: | CD16 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |