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| Catalog Code: | NB100-63462 |
| Product Name: | CD154 Antibody |
| Product Description: | Hamster Monoclonal anti-CD154 (39H5), conjugated to FITC |
| Clone: | 39H5 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | L cells transfected with CD40L |
| Specificity: | NB100-63462 recognises the murine CD154 cell surface antigen, a 39kD cell surface glycoprotein also known as CD40 ligand (CD40L). CD154 is expressed by activated CD4+ve T lymphocytes. This product is routinely tested in flow cytometry on mouse CD40L transfected L cells. |
| Cross Reactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Hamster ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell membrane: single pass type II membrane protein. Processed form: secreted protein. Also exists as an extracellular soluble form. |
| Background: | CD40 ligand (CD40L) is a 33 kDa type II membrane glycoprotein expressed mainly on the cell surface of activated T lymphocytes, but also exists as a soluble form extracellularly. CD40L is the ligand for CD40, a member of the TNF superfamily, which is expressed on the cell surface of B cells, macrophages/monocytes, dendritic cells, vascular endothelial cells, and epithelial cells. CD40L plays an important role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center through interaction with B cells expressing CD40, and activation of CD4+ T cells. Mutation within the CD40L gene is linked to hyper IgM syndrome, an X linked immunodeficiency disease that is characterized by elevated level of serum IgM and decreased level of other isotypes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host Name: | Hamster |
| Buffer: | Phosphate buffered saline, 1% Bovine Serum Albumin |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | Anti-CD 40L antibody; Anti-CD154 antibody; Anti-CD154 antigen antibody; Anti-CD40 antigen ligand antibody; Anti-CD40 homologue antibody; Anti-CD40 L antibody; Anti-CD40 ligand antibody; Anti-CD40LG antibody; Anti-gp39 antibody; Anti-hCD40L antibody; Anti-HIGM1 antibody; Anti-Hyper IgM syndrome antibody; Anti-IGM antibody; Anti-IMD3 antibody; Anti-Ly62 antibody; Anti-T B cell activating molecule antibody; Anti-T BAM antibody; Anti-T cell antigen GP39 antibody; Anti-TBAM antibody; Anti-TNF related activation protein antibody; Anti-TNF superfamily member 5 antibody; Anti-Tnfsf5 antibody; Anti-TRAP antibody; Anti-Tumor necrosis factor (ligand) superfamily member 5 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Conjugate: | FITC |
| General References: | 1. Hogg, K. G.et al. (2003) IL-10 regulates early IL-12-mediated immune responses induced by the radiation-attenuated schistosome vaccine. Int Immunol. 15(12):1451-1459 2. McGregor, C. M.et al. (2004) CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes. Proc Natl Acad Sci U S A. 101(25):9345-9350 |
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