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| Catalog Code: | NB100-63453 |
| Product Name: | CD152 Antibody |
| Product Description: | Mouse Monoclonal anti-CD152 (WKH203), conjugated to FITC |
| Clone: | WKH203 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | Purified rCTLA-4hIg fusion protein. |
| Specificity: | NB100-63453 recognises rat CD152, also known as cytotoxic-T-lymphocyte antigen-4 (CTLA-4), which is similar in structure to CD28 and also binds ligands CD80 and CD86. CD152 is expressed by activated T-lymphocytes and studies also suggest expression by regulatory T-lymphocytes (2). |
| Cross Reactivity: | Rat. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein. |
| Background: | CTLA4 has a critical role in T cell differentiation and contributes to the maintenance of peripheral T cell tolerance to self antigens. It exerts its major effects on T cell immune responses via regulation of the cell cycle and may be involved in T cell activation. It binds to B7-1 (CD80) and B7-2 (CD86), and it contains one immunoglobulin-like V type domain. It is widely expressed, with highest levels in lymphoid tissues. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline, 1% Bovine Serum Albumin |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Rt |
| Alternate Names: | Anti-CD152 antigen antibody; Anti-CD28 antibody; Anti-Celiac disease 3 antibody; Anti-CELIAC3 antibody; Anti-CTLA 4 antibody; Anti-Cytotoxic T cell associated 4 antibody; Anti-Cytotoxic T lymphocyte associated 4 antibody; Anti-Cytotoxic T lymphocyte associated antigen 4 antibody; Anti-Cytotoxic T lymphocyte associated protein 4 antibody; Anti-Cytotoxic T lymphocyte associated serine esterase 4 antibody; Anti-Cytotoxic T lymphocyte protein 4 antibody; Anti-GSE antibody; Anti-IDDM12 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Conjugate: | FITC |
| General References: | 1. Elflein, K. et al. (2003) Rapid recovery from T lymphopenia by CD28 superagonist therapy. Blood. 102: 1764-1770. 2. Lin, C-H. and Hunig, T. (2003) Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J. Immunol. 33: 626-638. |
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