| CatalogCode: | NB100-63436 |
| ProductName: | CD147 Antibody |
| Product Description: | Mouse Monoclonal anti-CD147 (MEM-M6/1), conjugated to FITC |
| Clone: | MEM-M6/1 |
| Clonality: | Monoclonal |
| Specificity: | NB100-63436 recognises the human CD147 cell surface antigen, a 50-60kD glycoprotein also known as neurothelin and basigin.CD147 is broadly expressed on peripheral blood cells and by endothelial cells. Expression upon T cells in increased following activation. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein |
| Background: | CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-5A11 antigen antibody; Anti-5F7 antibody; Anti-Basigin antibody; Anti-Blood-brain barrier HT7 antigen antibody; Anti-BSG antibody; Anti-CD 147 antibody; Anti-CD147 antigen antibody; Anti-Collagenase stimulatory factor antibody; Anti-Emmprin antibody Extracellular matrix metalloproteinase inducer antibody; Anti-Leukocyte activation antigen M6 antibody; Anti-M6 antibody; Anti-M6 antigen antibody; Anti-neurothelin antibody; Anti-OK antibody; Anti-OK blood group antibody; Anti-OK blood group antigen antibody; Anti-TCSF antibody; Anti-Tumor cell derived collagenase stimulatory factor antibody |
| ProteinTarget: | CD147 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. Koch, C. et al. (1999) T cell activation -associated epitopes of CD147 in regulation of the T cell response and their definition by antibody affinity and antigen density. Int. Immunol. 11: 777-786. |
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