| CatalogCode: | NB100-63416 |
| ProductName: | CD137L Antibody |
| Product Description: | Rat Monoclonal anti-CD137L (AT113-2), conjugated to PE |
| Clone: | AT113-2 |
| Clonality: | Monoclonal |
| Immunogen: | 41BBL-Fc Fusion Protein |
| Specificity: | NB100-63416 recognises murine 4-1BB Ligand (CD137L), a 50kD type 2 transmembrane protein, which is a member of the TNF superfamily. In mice CD137L is expressed on activated T-cells, B-cells, macrophages and dendritic cells. Interaction of CD137L with its receptor 4-1BB (CD137) is reported to be involved in T and B cell growth and T cell effector function. |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 100 tests protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Background: | CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-4 1BB ligand antibody; Anti-4 1BBL antibody; Anti-Cd137l antibody; Anti-Cd157l antibody; Anti-ILA ligand (TNF related) antibody; Anti-Ly63l antibody; Anti-Tumor necrosis factor (ligand) superfamily member 9 antibody |
| ProteinTarget: | CD137L |
| PackageSize: | 100 tests |
| Conjugate: | PE |
| GeneralRef: | 1. Goodwin, R.G. et al. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23: 2631-41. |
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