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| Catalog Code: | NB100-63400 |
| Product Name: | CD13 Antibody |
| Product Description: | Rat Monoclonal anti-CD13 (R3-63), conjugated to FITC |
| Clone: | R3-63 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 0.1 mg/ml |
| Immunogen: | Mouse intestinal APN |
| Specificity: | NB100-63400 recognises mouse aminopeptidase N (APN), a cell surface protein homologous with human CD13. In the mouse, CD13 is a non-covalently linked homodimer of approximately 150kD subunits expressed by a variety of cells including monocytes, macrophages, dendritic cell and veiled cells. Clone R3-63 has been reported to block mouse APN enzyme activity (1). |
| Cross Reactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.05 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell membrane; single-pass type II membrane protein |
| Background: | Human CD13 is expressed on the majority of peripheral blood monocytes and granulocytes. It is also expressed by the majority of acute myeloid leukemias, chronic myeloid leukemias in myeloid blast crisis, a smaller percentage of lymphoid leukemias and myeloid cell lines. CD13 is also found in several types of non hematopoietic cells such as fibroblasts and endothelial cells and in a soluble form in blood plasma. CD13 is not expressed on B cells, T cells, platelets or erythrocytes. In the mouse, CD13 is a non-covalently linked homodimer of approximately 150kD subunits expressed by a variety of cells including monocytes, macrophages, dendritic cell and veiled cells. CD13 plays a role in biologically active peptide metabolism, in the control of growth and differentiation, in phagocytosis and in bactericidal/tumoricidal activities. CD13 also serves as a receptor for human coronaviruses (HCV). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Mu |
| Alternate Names: | Anti-Alanyl aminopeptidase antibody, Anti-Alanyl membrane aminopeptidase antibody, Anti-Aminopeptidase M antibody, Anti-Aminopeptidase N antibody, Anti-ANPEP antibody, Anti-APN antibody, Anti-CD 13 antibody, Anti-CD13 antigen antibody, Anti-gp150 antibody, Anti-hAPN antibody, Anti-Lap 1 antibody, Anti-Lap1 antibody, Anti-Microsomal aminopeptidase antibody, Anti-Myeloid plasma membrane glycoprotein CD13 antibody, Anti-p150 antibody, Anti-PEPN antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.09% Sodium Azide |
| Conjugate: | FITC |
| General References: | 1. Hansen, A. S. et al. (1993) A mouse aminopeptidase N is a marker for antigen-presenting cells and appears to be co-expressed with major histocompatibilty complex class II molecules. Eur. J. Immunol. 23: 2358 - 2364. 2. Larsen, S .L. et al. (1996) T cell responses affected by aminopeptidase N (CD13) - mediated trimming of major histocompatibility complex. J. Exp. Med. 184: 183 - 189. |
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