| CatalogCode: | NB100-63384 |
| ProductName: | CD123 Antibody |
| Product Description: | Rat Monoclonal anti-CD123 (5B11) |
| Clone: | 5B11 |
| Clonality: | Monoclonal |
| Immunogen: | CTLL cells transfected with mouse CD123. |
| Specificity: | NB100-63384 recognises murine CD123, which is the 70kD alpha chain of the interleukin-3 receptor (IL-3R). CD123 is expressed on haematopoietic progenitors and most myeloid cells including basophils and mast cells. Certain mouse strains including A/J, AKR/J and NZB/B1NJ are reported to have low levels of CD123 expression due to aberrant splicing of the IL-3R alpha subunit gene.In mouse, CD123 can associate with either the common beta subunit CDw131 or with the murine IL-3 beta subunit to form a high affinity receptor for IL-3. IL-3 can bind to CD123 itself but with low affinity. Binding of IL-3 to the IL-3 receptor complex induces the proliferation and differentiation of haematopoietic cells.Clone 5B11 does not block the binding of IL-3 to the high affinity IL-3 receptor. |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4 |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-CD123 antibody; Anti-hIL3Ra antibody; Anti-IL3R antibody; Anti-IL3RAY antibody; Anti-IL3RX antibody; Anti-IL3RY antibody; Anti-MGC34174 antibody |
| ProteinTarget: | CD123 |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Ichihara, M. et al. (1995) Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J. 14:939 - 950. |
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