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| Catalog Code: | NB100-63370 |
| Product Name: | CD11c Antibody |
| Product Description: | Mouse Monoclonal anti-CD11c (BU15), conjugated to PE |
| Clone: | BU15 |
| Clonality: | Monoclonal |
| ListPrice: | 315 |
| Specificity: | NB100-63370 recognises the integrin alphax subunit, a 150kD glycoprotein expressed by macrophages, monocytes, granulocytes and NK cells. The antigen is also expressed by hairy cell leukaemia cells. Ligands for CD11c are ICAM-1, iC3b, and fibrinogen. The molecule has a role in mediating adherence of granulocytes and monocytes to endothelium and fibrinogen. |
| Cross Reactivity: | Human. Not yet tested in other species. |
| Packaging: | 100 tests Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | CD11c (integrin alpha X chain protein) combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as inactivated C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. The CD11c antigen is a marker for hairy cell leukaemia. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | Anti-INTEGRIN ALPHA X CHAIN antibody |
| Package Size: | 100 tests |
| Preservative: | Sodium Azide |
| Conjugate: | PE |
| General References: | 1. Hogg, N. et al. (1986) The p150, 95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. Eur. J. Immunol. 16: 240 - 248. 2. Loike, J.D. et al. (1991) CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen. Proc. Natl. Acad. Sci. USA 88: 1044-1048. 3. Larson, R.S. and Springer, T.A. (1990) Structure and function of leukocyte integrins. Immunol. Rev. 114: 181-217. 4. Sanchez-Madrid, F. and Corbi, A.L. (1992) Leukocyte integrins: structure, function and regulation of their activity. Seminars Cell Biol. 3: 199-210. 5. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp. Anim. 49 (2): 97-110. 6. Trowald-Wigh, G. et al. (1993) Canine neutrophil adhesion proteins and Fc receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry. Vet. Immunol. Immunopathol. 38: 297- 310. |
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