| CatalogCode: | NB100-63350 |
| ProductName: | CD11a Antibody |
| Product Description: | Mouse Monoclonal anti-CD11a (WT.1), conjugated to PE |
| Clone: | WT.1 |
| Clonality: | Monoclonal |
| Immunogen: | Splenic PHA blasts |
| Specificity: | NB100-63350 reacts with rat CD11a, a glycoprotein of 160-170 kD which is associated with CD18. CD11a is one of the leucocyte integrins (b2 integrin) which plays an important part in leucocyte physiology. Functionally, this monoclonal inhibits homotypic aggregation of PHA blasts. It also blocks binding of rat lymphocytes to purified rat ICAM-1. |
| CrossReactivity: | Rat. Not yet tested in other species. |
| Packaging: | 100 tests Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Membrane; single pass type I membrane protein. |
| Background: | CD11a is a member of the integrin family of cell adhesion molecules. It is a glycoprotein expressed in combination with the CD18 beta chain. The complex is a member of the beta 2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM2, ICAM3. CD11a is expressed on thymocytes, T and B lymphocytes, granulocytes, monocytes, and macrophages. This antibody blocks CD11a functions. CD11a is expressed on human leucocytes, with greater expression on memory T cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.2, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Rt |
| ProteinTarget: | CD11a |
| PackageSize: | 100 tests |
| Conjugate: | PE |
| GeneralRef: | 1. Tamantani, T. et al. (1991) Molecular mechanisms underlying lymphocyte recirculation. II Differential regulation of LFA-1 in interaction between lymphocytes and high endothelial cells. Eur. J. Immunol. 21: 627-633. 2. Tamatani, T. et al. (1991) Characterisation of the rat leucocyte integrin, CD11/CD18 by the use of monoclonal antibodies. Eur. J. Immunol. 21: 855-858. |