| CatalogCode: | NB100-63341 |
| ProductName: | CD117 Antibody |
| Product Description: | Rat Monoclonal anti-CD117 (2B8) |
| Clone: | 2B8 |
| Clonality: | Monoclonal |
| Immunogen: | IL-3 dependent mast cells |
| Specificity: | NB100-63341 recognises mouse CD117, a 150kD cell surface molecule that is otherwise known as the Kit, or c-kit, receptor. Clone 2B8 recognises an epitope within the extracellular region of CD117. In mice, CD117 is predominantly expressed on multipotent haematopoietic stem cells from the adult bone marrow and foetal liver. |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.25 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Plasma membrane; type I membrane protein. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2b |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4 |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-C Kit antibody; Anti-CD 117 antibody; Anti-CD117 antibody; Anti-CD117 antigen antibody; Anti-KIT antibody; Anti-Mast/stem cell growth factor receptor antibody; Anti-PBT antibody; Anti-Proto oncogene tyrosine protein kinase Kit antibody; Anti-SCF Receptor antibody; Anti-SCFR antibody; Anti-Stem cell factor receptor antibody; Anti-v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog antibody |
| ProteinTarget: | CD117 |
| PackageSize: | 0.25 mg |
| GeneralRef: | 1. Ikuta, K. and Weissman, I.L. (1992) Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc. Natl. Acad. Sci. USA 89: 1502-1506. 2. Fleming, W.H., Alpern, E.J., Uchida, N., Ikuta, K. and Weissman, I.L. (1993) Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo. Proc. Natl. Acad. Sci. USA 90: 3760-3764. 3. Rico-Vargas, S.A., Weiskopf, B., Nishikawa, S.I. and Osmond, D. (1994) c-kit expression by B cell precursors in mouse bone marrow. J. Immunol. 152: 2845-2852. 4. Manova, K., Bachvarova, R.F., Hunag, E.J., Sanchez, S., Pronovast, S.M., Velazquez, E., McGuire, B. and Besmer, P. (1992) c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons. J. Neurosci. 12: 4663-4676. |
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