| CatalogCode: | NB100-63326 |
| ProductName: | CD104 Antibody |
| Product Description: | Mouse Monoclonal anti-CD104 (450-9D), conjugated to FITC |
| Clone: | 450-9D |
| Clonality: | Monoclonal |
| Immunogen: | Purified a6b4 integrin from A431 cells |
| Specificity: | NB100-63326 recognises the human b4 integrin (also known as CD104), a 205kD glycoprotein which associates with the a6 integrin to form the a6/b4 complex. CD104 is expressed on epithelial cells, Schwann cells and various tumour cell lines. MCA1456 recognises an extracellular epitope on the CD104 molecule. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Cell Membrane; single pass type I membrane protein |
| Background: | Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CD 104 antibody; Anti-CD104 antibody; Anti-CD104 antigen antibody; Anti-GP150 antibody; Anti-ITG B4 antibody; Anti-ITGB 4 antibody; Anti-ITGB4 antibody |
| ProteinTarget: | CD104 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. Kennel, S.J. et al. (1990) Second generation monoclonal antibodies to the human integrin a6b4. Hybridoma 9: 243-254. |