| CatalogCode: | NB100-63323 |
| ProductName: | CD102 Antibody |
| Product Description: | Rat Monoclonal anti-CD102 (mIC2/4 (3C4)), conjugated to FITC |
| Clone: | mIC2/4 (3C4) |
| Clonality: | Monoclonal |
| Immunogen: | COS cells transfected with murine ICAM-2 |
| Specificity: | NB100-63323 recognises murine intercellular adhesion molecule-2 (ICAM-2), also known as CD102. Murine CD102 is a glycosylated cell surface protein that is broadly expressed on most leucocytes and is constitutively expressed on endothelial cells. CD102 interacts with the CD11a/CD18 integrin LFA-1. Reports suggest that CD102 may play a role in lymphocyte re-circulation and T-cell activation.Clone mIC2/4 is reported to inhibit interactions between CD102 and LFA-1(1). |
| CrossReactivity: | Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Rat ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type I membrane protein |
| Background: | ICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin like C2 type domains, and bind to the leukocyte adhesion LFA1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA1 dependent cell adhesion. It mediates adhesive interactions important for antigen specific immune response, NK cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Rat |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Mu |
| ALTnames: | Anti-CD102 antigen antibody; Anti-ICAM 2 antibody; Anti-Intercellular adhesion molecule 2 precursor antibody; Anti-Ly60 antibody |
| ProteinTarget: | CD102 |
| PackageSize: | 0.1 mg |
| Conjugate: | FITC |
| GeneralRef: | 1. Xu, H. et al. (1996) Characterization of murine intercellular adhesion molecule - 2. J. Immunol. 156:4909 - 4914. 2. Soede, R.D. et al. (1999) LFA-1 to LFA-1 signals involve zeta-associated protein-70 (ZAP-70) tyrosine kinase: Relevance for invasion and migration of a T-cell hybridoma. J. Immunol. 163:4253-4261. |