| CatalogCode: | NB100-63318 |
| ProductName: | CD102 Antibody |
| Product Description: | Mouse Monoclonal anti-CD102 (CBRIC2/2), conjugated to Biotin |
| Clone: | CBRIC2/2 |
| Clonality: | Monoclonal |
| Immunogen: | Transfected COS cells expressing ICAM-2 cDNA |
| Specificity: | NB100-63318 recognises human CD102, also known as intercellular adhesion molecule-2 (ICAM-2). CD102 is a glycosylated cell surface protein that is broadly expressed on most leucocytes and is strongly expressed by endothelial cells. CD102 interacts with the CD11a/CD18 (LFA-1). Reports suggest that the CD102 may play a role in lymphocyte re-circulation and T-cell activation.Clone CBR-IC2/2 is reported to inhibit interactions between CD102 and LFA-1(1). |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein G purified Mouse ascites. |
| Uses: | This antibody is useful for flow cytometry / FACS analysis |
| Localization: | Type II membrane protein. |
| Background: | ICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin like C2 type domains, and bind to the leukocyte adhesion LFA1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA1 dependent cell adhesion. It mediates adhesive interactions important for antigen specific immune response, NK cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4, 1% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Intercellular adhesion molecule 2 precursor antibody; Anti-CD 10 antibody; Anti-CD102 antigen antibody; Anti-ICAM 2 antibody; Anti-Ly60 antibody; Anti-Membrane metallo endopeptidase antibody |
| ProteinTarget: | CD102 |
| PackageSize: | 0.1 mg |
| Conjugate: | Biotin |
| GeneralRef: | 1. De Fougerolles, A.R. et al. (1991) Characterization of ICAM-2 and Evidence for a Third Counter-Receptor for LFA-1. J. Exp. Med. 174:253-267. 2. Diacovo, T.G. et al. (1994) A Funtional Integrin Ligand on the Surface of Platelets: Intercellular Adhesion Molecule-2. J. Clin. Invest. 94:1243-1251. |
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