| CatalogCode: | NB100-63275 |
| ProductName: | IL-2 Antibody |
| Product Description: | Rabbit Polyclonal anti-IL-2 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant human IL-2 |
| Specificity: | NB100-63275 is specific for human IL-2 (Interleukin-2), otherwise known as T-cell growth factor, a 133 amino acid glycoprotein and potent immunoregulatory cytokine produced by antigen or mitogen stimulated T cells.IL-2 is a multi-functional cytokine which signals through the IL-2 receptor complex (IL-2R), and is principally involved in the stimulation of the T cell proliferative response, promoting T cell clonal expansion and the expansion of T memory cells expressing low levels of high-affinity IL-2R.IL-2 also stimulates the growth/differentiation of B cells, monocytes, NK cells, macrophages and lymphokine activated killer cells. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot, Functional |
| Localization: | Secreted |
| Background: | Human interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL-2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, pH7.4 |
| ListPrice: | 360 |
| AppSummary: | ELISA, WB, FC |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Aldesleukin antibody; Anti-IL 2 antibody; Anti-Interleukin 2 antibody; Anti-Interleukin2 antibody; Anti-Lymphokine antibody; Anti-T Cell Growth Factor antibody; Anti-TCGF antibody |
| ProteinTarget: | IL-2 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Fujita, T. et al. (1983) Structure of the human Interleukin 2 gene. P.N.A.S. 80: 7437-7441. 2. Nelson, B.H. (2004) IL-2, regulatory T cells, and tolerance. J. Immunol. 172: 3983-3988. |
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