| CatalogCode: | NB100-63251 |
| ProductName: | VDR Antibody |
| Product Description: | Goat Polyclonal anti-VDR |
| Clonality: | Polyclonal |
| Immunogen: | Peptide sequence CGNQDYKYRVSD corresponding to the internal region of VDR (NP_000367.1). |
| Specificity: | NB100-63251 recognises human vitamin D nuclear hormone receptor (VDR) a 48 kDa member of the trans-acting transcriptional regulatory factors. On binding vitamin D, VDR regulates the expression of hormone sensitive genes. The main downstream target of VDR is involved in bone mineral metabolism although VDR is also involved in immune response and cancer metabolic pathways. VDR also acts as a receptor for secondary bile acid lithocholic acid. Additionally, signalling and oncogenic activity of beta-catenin signalling has been shown to be repressed by VDR. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Goat antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Nuclear |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | TRIS buffered saline, pH7.3, 0.5% Bovine Serum Albumin |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Vitamin D3 receptor antibody; Anti-125 dihydroxyvitamin D3 receptor antibody; Anti-NR1I1 antibody; Anti-Vitamin D hormone receptor antibody |
| ProteinTarget: | VDR |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Cheng, H. et al. (2006) Functional role of VDR in the activation of p27Kip1 by the VDR/Sp1 complex. J. Cell. Biochem. 98:1450-1456. |