| CatalogCode: | NB100-63236 |
| ProductName: | SYK Antibody |
| Product Description: | Goat Polyclonal anti-SYK |
| Clonality: | Polyclonal |
| Immunogen: | Peptide with sequence C-KYLQQNRHVKDKN from the internal region of the SYK sequence. |
| Specificity: | NB100-63236 detects an epitope within the internal region of SYK, a 70kD non-receptor protein tyrosine kinase whose role differs in haematopoietic and non haematopoietic stem cells. In haematopoietic cells SYK is involved in the proximal signalling downstream of activated immunoreceptors (BCR, TCR, Fc receptors), thereby orchestrating a complex series of cellular responses such as cell proliferation, differentiation, survival and phagocytosis. In epithelial cells SYK appears to function as a negative regulator of related events. Furthermore, SYK has been shown to promote expression or secretion of inflammation-related molecules in lung epithelial cells. SYK appears to be required for vascular integrity during development, thus, manipulation of SYK function in endothelial cells could potentially modulate tumour-associated angiogenesis. SYK also has been shown to interact with Epstein-Barr virus LMP2A. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Goat antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Cytoplasmic: T cell receptor complex |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | TRIS buffered saline, pH7.3, 0.5% Bovine Serum Albumin |
| ListPrice: | 340 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Spleen tyrosine kinase antibody; Anti-Tyrosine protein kinase SYK antibody |
| ProteinTarget: | SYK |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Coopman, P.J. and Mueller, S.C. (2006) The Syk tyrosine kinase: a new negative regulator in tumour growth and progression. Cancer Lett. 241: 159-173. 2. Wong, B.R. et al. (2004) Targeting Syk as a treatment allergic and autoimmune disorders. Expert Opin. Investig. Drugs. 13: 743-762. |
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