| CatalogCode: | NB100-63231 |
| ProductName: | SOCS-3 Antibody |
| Product Description: | Mouse Monoclonal anti-SOCS-3 (SO1) |
| Clone: | SO1 |
| Clonality: | Monoclonal |
| Immunogen: | Full - length SOCS3 protein. |
| Specificity: | NB100-63231 recognizes suppressor of cytokine signaling 3 (SOCS3), a 30kDa member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways.SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS3 is inducible by numerous factors, including IL-6, IL-10, Toll-like receptor (TLR) agonists and IFN gamma, making this protein the focus of research into inflammatory diseases, such as Arthritis, Colitis, and Crohn's Disease. SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumour studies. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Cytoplasmic |
| Background: | SOCS3 is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity and thereby suppressing cytokine signaling. It is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. To date, there are eight members of SOCS family that have been recognized. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain and a previously unrecognized C-terminal motif that has been called the SOCS box. The expression of the SOCS3 gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. Studies of the mouse counterpart of the SOCS3 gene suggested this gene is involved in the negative regulation of fetal liver hematopoiesis, and placental development. Recent findings suggest that aberrant induction of SOCS3 by pathogens, such as Leishmania donovani and hepatitis C virus, might interfere with the host immune response and contribute to the persistent infection by these pathogens. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG2b |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline pH7.4 |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-ATOD4 antibody; Anti-CIS 3 antibody; Anti-CIS3 antibody; Anti-Cish3 antibody; Anti-Cytokine induced SH2 protein 3 antibody; Anti-E2a Pbx1 target gene in fibroblasts 10 antibody; Anti-EF 10 antibody; Anti-MGC71791 antibody; Anti-SOCS 3 antibody; Anti-SSI 3 antibody; Anti-SSI3 antibody; Anti-STAT induced STAT inhibitor 3 antibody; Anti-Suppressor of cytokine signaling 3 antibody |
| ProteinTarget: | SOCS-3 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Lehmann, U. et al. (2003) SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. J Biol. Chem. 278(1): 661-671. 2. Suzuki, A. et al. (2001) CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193(4): 471-481. 3. Lang, R. et al. (2003) SOCS3 regulates the plasticity of gp130 signaling. Nature Immunology 4(6): 546-550. 4. Sakai, I. et al. (2002) Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells. Blood 100(8): 2926-2930. |
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