| CatalogCode: | NB100-63213 |
| ProductName: | PIM-2 Antibody |
| Product Description: | Human Monoclonal anti-PIM-2 (2181) |
| Clone: | 2181 |
| Clonality: | Monoclonal |
| Immunogen: | Full length human PIM-2 fusion protein (Met1-Pro311, 34 kDa). |
| Specificity: | NB100-63213 is specific for PIM-2, a serine/threonine-protein kinase. It does not cross-react with human kinases PIM-1, CHK, CSK, TSF1 and PCTAIRE1, as measured by indirect ELISA and/or Western blotting.PIM-2 belongs to a family of cytoplasmic serine/threonine protein kinases that consists of two other members, PIM-1 and PIM-3. Expression of this protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is also highly expressed in human leukemic and lymphoma cell lines. The gene is also expressed in primary spermatocytes. The results suggest a role for PIM-2 in proliferating cells as well as during meiosis. PIM-2 is thought to be a mediator of p53-mediated apoptosis inhibition by interleukin-3, which supports its role in the formation of various tumours including lymphomas. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Human ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | HuCAL Fab bivalent |
| Host_Name: | Human |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Pim 2h antibody; Anti-PIM2 Oncogene antibody; Anti-Pim2h antibody; Anti-Proto Oncogene PIM2 antibody; Anti-Serine/threonine kinase PIM2 antibody |
| ProteinTarget: | PIM-2 |
| PackageSize: | 0.1 mg |
| NotesMain: | Lyophilized - reconstitute with 0.1ml distilled water. |