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| Catalog Code: | NB100-63167 |
| Product Name: | hCG HOLO Antibody |
| Product Description: | Mouse Monoclonal anti-hCG HOLO (INN-hCG-53) |
| Clone: | INN-hCG-53 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 1.0 mg/ml |
| Specificity: | NB100-63167 recognises epitope c2 on hCG. It does not recognise free hCG subunits. |
| Cross Reactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.5 mg Mouse ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Secreted |
| Background: | Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced by trophoblastic cells of the placenta beginning 10 to 12 days after conception. Maintenance of the fetus in the first trimester of pregnancy requires the production of hCG, which binds to the corpus luteum of the ovary which is stimulated to produce progesterone which in turn maintains the secretory endometrium. hCG is present only in trace amounts in non pregnant urine and sera. It rises sharply during pregnancy. HCG is composed of two non identical, non covalently linked polypeptide chains designated as the a and b subunits. The a subunit of HCG is nearly identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH) and luteinizing hormone (LH). A germ cell tumor which is positive for cytokeratin, placental alkaline phosphatase (PLAP) and HCG but negative for EMA and AFP is probably a choriocarcinoma. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.2 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | Anti-Choriogonadotropin holo c2 antibody; Anti-Human Chrionic Gonadotropin holo c2 antibody |
| Package Size: | 0.5 mg |
| Preservative: | 0.09% Sodium Azide |
| General References: | 1. Lei, Z. et al. (1993) Novel coexpression of human chorionic gonadotropin (hCG)/human luteinizing hormone receptors and their ligand hCG in human fallopian tubes. J. Clin. Endocrinol. Metab. 77: 863 - 872. 2. Ben-Menahem, D. et al. (2001) The position of the alpha and beta subunits in a single chain variant of human chorionic gonadotrophin affects the heterodimeric interaction of the subunits and receptor-binding epitopes. J. Biol. Chem. 276: 29871-29879. 3. Jackson, A. M. et al. (1999) The biological action of choriogonadotropin is not dependent on the complete native quaternary interactions between the subunits. Mol. Endocrinol. 13: 2175 - 2188. |
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