| CatalogCode: | NB100-63164 |
| ProductName: | GUANYLATE CYCLASE BETA 1 Antibody |
| Product Description: | Mouse Monoclonal anti-GUANYLATE CYCLASE BETA 1 (GC11) |
| Clone: | GC11 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant human soluble guanylate cyclase á1ß1 heterodimer. |
| Specificity: | NB100-63164 detects the beta1 subunit of guanylate cyclase, a heterodimeric protein consisting of an alpha subunit and a beta subunit linked by disulphide bonds. Guanylate cyclase functions as the main receptor for nitric oxide, whereupon it catalyzes the conversion of GTP to the second messenger cGMP. cGMP mediates the vasodilator capacity of NO, and is important in modulating other vascular functions, including cellular proliferation, apoptosis, migration and extracellular matrix production. Guanylate cyclase beta1 has recently been shown to be upregulated in mononuclear cells from patients with erectile dysfunction. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.2 mg protein A purified Mouse ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Cytoplasmic |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG2b |
| Host_Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4 |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-GUCSB3 antibody; Anti-GCS beta 1 antibody; Anti-GCS beta 3 antibody; Anti-Guanylate cyclase soluble beta 1 chain antibody; Anti-GUC1B3 antibody; Anti-GUCY1B1 antibody; Anti-GUCY1B3 antibody; Anti-Soluble guanylate cyclase small subunit antibody |
| ProteinTarget: | GUANYLATE CYCLASE BETA 1 (SOLUBLE) |
| PackageSize: | 0.2 mg |
| GeneralRef: | 1. Sinnaeve, P. et al. (2001) Soluble guanylate cyclase alpha(1) and beta(1) gene transfer increases NO responsiveness and reduces neointima formation after balloon injury in rats via antiproliferative and antimigratory effects. Circ. Res. 88: 103-109. 2. Mateos-Cáceres, P.J. et al. (2006) Soluble guanylate cyclase â1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. Int. J. Impot. Res. 18(5):432-7. |
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