| CatalogCode: | NB100-63153 |
| ProductName: | FOXO3A Antibody |
| Product Description: | Goat Polyclonal anti-FOXO3A |
| Clonality: | Polyclonal |
| Immunogen: | Peptide sequence C-GAKQASSQSWVPG corresponding to the N-terminus of FOXO3A . |
| Specificity: | NB100-63153 recognises human forkhead box O3A (FOXO3A), also known as FKHLR1. This is a 95kDa member of the forkhead family of transcription factors. FOXO3A is ubiquitously expressed and is an important regulator of apoptosis and the cell cycle. FOXO3A triggers apoptosis by inducing the expression of genes necessary for cell death. In association with RUNX3, FOXO3a is involved in the induction of Bim expression and apoptosis. Translocation t(6;11)(q21;q23) of FOXO3A with the mixed-lineage leukaemia gene is associated with secondary acute leukaemia. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Goat antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Cytoplasmic and Nuclear |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| ListPrice: | 340 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-AF6q21 antibody; Anti-AF6q21 protein antibody; Anti-DKFZp781A0677 antibody; Anti-FKHR2 antibody; Anti-FKHRL 1 antibody; Anti-FKHRL1 antibody; Anti-FKHRL1P2 antibody; Anti-Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1 antibody; Anti-Forkhead box O3A antibody; Anti-Forkhead box protein O3A antibody; Anti-Forkhead Drosophila homolog of in rhabdomyosarcoma like 1 antibody; Anti-Forkhead in rhabdomyosarcoma like 1 antibody; Anti-FOX O3A antibody; Anti-MGC12739 antibody; Anti-MGC31925 antibody |
| ProteinTarget: | FOXO3A |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Dijkers, P. et al. (2002) FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156:531-542. |