| CatalogCode: | NB100-63148 |
| ProductName: | EGF R Antibody |
| Product Description: | Rabbit Polyclonal anti-EGF R |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acids 1189-1199 of human EGF receptor protein. |
| Specificity: | NB100-63148 detects human epidermal growth factor receptor (EGFR), a 170kD transmembrane glycoprotein which is a member of the ErbB family of receptor tyrosine kinases. EGFR is the cell surface receptor for members of the EGF family, and functions in early embryonic development and in the renewal of stem cells in tissues such as the skin, liver and gut.Mutations to EGFR have been found in many human carcinomas including breast, brain, lung, and colon. Over-expression of more than one member of the ErbB family was found to have a negative synergistic effect on patient outcome. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.05 mg Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Background: | Epidermal growth factor (EGF) has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells. The EGF precursor is believed to exist as a membrane-bound molecule which is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. EGF exerts its actions by binding to the EGFR, a 170 kDa protein. Epidermal growth factor (EGF) is a key growth factor regulating cell survival. Through its binding to cell surface receptors, EGF activates an extensive network of signal transduction pathways that include activation of the PI3K/AKT, RAS/ERK and JAK/STAT pathways. Because of its key role in driving the proliferation of cells, EGFR is a target of several anti-cancer drugs currently in development. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline, pH7.2 |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-EPIDERMAL GROWTH FACTOR RECEPTOR antibody |
| ProteinTarget: | EGF R |
| PackageSize: | 0.05 mg |
| GeneralRef: | 1. Sebastian, S. et al. (2006) The complexity of targeting EGFR signalling in cancer: from expression to turnover. Biochim. Biophys. Acta. 1766: 120-39. 2. Normanno, N. et al. (2006) Epidermal growth factor receptor (EGFR) signaling in cancer. Gene. 366: 2-16. |
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