| CatalogCode: | NB100-63138 |
| ProductName: | CYCLOPHILIN A Antibody |
| Product Description: | Human Monoclonal anti-CYCLOPHILIN A (794) |
| Clone: | 794 |
| Clonality: | Monoclonal |
| Immunogen: | Full length human recombinant cyclophilin A, amino acid residues 1-164. MW 17.9 kDa. |
| Specificity: | NB100-63138 recognises Cyclophilin A (also designated peptidyl-prolyl cis/trans isomerase A or PPIA) ia a ubiquitously distributed intracellular protein that can be secreted by cells in response to inflammatory stimuli. Cyclophilin A is a member of the immunophilin class of proteins that all possess peptidyl-prolyl cis/trans isomerase activity and, therefore, are believed to be involved in protein folding and/or intracellular protein transport. This protein can interact with several HIV proteins including p55 gag, Vpr, and capsid protein. It has been shown to be necessary for the formation of infectious HIV virions. Cyclophilin is a specific high-affinity binding protein for the immunosuppressant agent cyclosporin A. Because of its dramatic effects on decreasing morbidity and increasing survival rates in human transplants, the molecular mechanism of immunosuppression by cyclosporin A has been a matter of much interest. Multiple PPIA pseudogenes that map to different chromosomes have been reported. Three alternatively spliced transcript variants encoding two distinct isoforms have been observed. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Human ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | HuCAL Fab bivalent |
| Host_Name: | Human |
| Buffer: | Phosphate buffered saline |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | CYCLOPHILIN A |
| PackageSize: | 0.1 mg |
order or
more information: | company product webpage |
| request information: |
|