| CatalogCode: | NB100-63133 |
| ProductName: | CHOLESTEROL 24-HYDROXYLASE Antibody |
| Product Description: | Goat Polyclonal anti-CHOLESTEROL 24-HYDROXYLASE |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide corresponding to amino acid sequence 254-270 of human cholesterol 24-hydroxylase protein. |
| Specificity: | NB100-63133 recognises cholesterol 24-hydroxylase (CYP46A1), a 58 kDa member of the Cytochrome P450 family, expressed in the brain. CYP46A1 converts cholesterol into the biologically active oxysterol and 24(S)-hydroxycholesterol, in the first step of the enzymatic degradation of cholesterol in the brain. CYP46A1 is also thought to play a role in the metabolism of neurosteroids and drugs that can cross the blood-brain barrier and are targeted to the central nervous system.P450 enzymes are divided into two groups: steroidogenic and xenobiotic. The latter group is comprised of three families 1, 2 and 3. The xenobiotic p450's are involved in most oxidative drug metabolism. Work in this area is ongoing but studies suggest that all known drug metabolism is mediated by family members: CYP3A, CYP2D6, CYP1A2, CYP2C9/10, CYP2C19 and CYP2E1. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Whole antisera Goat antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Goat |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CYP46 antibody |
| ProteinTarget: | CHOLESTEROL 24-HYDROXYLASE (C-TERMINAL) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Pikuleva IA. (2006) Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther. 112:761-73. 2. Mast, N. et al. (2003) Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 42:14284-14292. 3. Ng, P. et al. (2003) Production of inhibitory polyclonal antibodies against cytochrome P450s. Drug Metabol. Pharmacokin. 18(3):163-172. |