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| Catalog Code: | NB100-63123 |
| Product Name: | CASPASE-2 Antibody |
| Product Description: | Mouse Monoclonal anti-CASPASE-2 (1C10) |
| Clone: | 1C10 |
| Clonality: | Monoclonal |
| ListPrice: | 385 |
| Concentration: | 1.0mg/ml |
| Immunogen: | Recombinant human caspase-2 (32-169aa) purified from E.coli. |
| Specificity: | NB100-63123 recognises recombinant mouse anti-human caspase-2, a 53 kDa member of the cysteine-aspartic acid protease (caspase) family. Caspase-2 is required for the permeabilisation of the mitochondria and the resulting amplification of caspase activity, in response to cytotoxic stress. Cytotoxic stress induced proteolytic cleavage of the caspase-2 proenzyme forms an active caspase which cleaves other caspases in a cascade. This leads to the release of cytochrome c and Smac from mitochondria and the translocation of Bax from the cytoplasm to the mitochondria, leading to apoptosis. In adults, caspase-2 is expressed in the placenta, lung, kidney, pancreas and at lower levels in the heart, brain, liver and skeletal muscle. |
| Cross Reactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 ml Affinity purified Mouse ascites. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Background: | Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG2b |
| Host Name: | Mouse |
| Buffer: | Phosphate buffered saline, pH7.4 |
| Application Summary: | ELISA, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | Anti-Apoptosis related cysteine peptidase antibody, Anti-CASP 2 antibody, Anti-Casp 2L Pro antibody, Anti-CASP2 antibody, Anti-Caspase 2 apoptosis related cysteine protease antibody, Anti-Caspase2 antibody, Anti-Developmentally down regulated 2 antibody, Anti-ICH 1 antibody, Anti-ICH 1 protease antibody, Anti-ICH 1L antibody, Anti-ICH 1L/1S antibody, Anti-ICH1 antibody, Anti-ICH1 protease antibody, Anti-ICH1L antibody, Anti-ICH1L/1S antibody, Anti-NEDD 2 antibody, Anti-NEDD2 antibody, Anti-NEDD2 apoptosis regulatory gene antibody, Anti-Neural precursor cell expressed antibody, Anti-Neural precursor cell expressed developmentally down regulated 2 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.09% Sodium Azide |
| General References: | 1. Lassus, P. et al. (2004) Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297: 1352-1354, 2002. Note: Correction: Science 306: 1638 only. |
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