| CatalogCode: | NB100-63106 |
| ProductName: | Bcl-2 Antibody |
| Product Description: | Goat Polyclonal anti-Bcl-2 |
| Clonality: | Polyclonal |
| Immunogen: | Peptide with sequence AGRTGYDNREIVMKYC from N-terminal of Bcl-2. |
| Specificity: | NB100-63106 detects an epitope within the N-terminal (NT) region of Bcl-2, a 25kD integral outer mitochondrial membrane protein that blocks apoptotic death in a variety of cell systems. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability. It inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (apaf-1). Bcl-2 is antiproliferative by facilitating G0 entry. Constitutive expression of Bcl-2 is thought to be the cause of follicular lymphoma, also known as type II chronic lymphatic leukaemia. Bcl-2 mutations have also been found in Non-Hodgkin Lymphomas. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Goat antisera. |
| Uses: | This antibody is useful for ELISA, Western Blot |
| Localization: | Endoplasmic reticulum, outer mitochondrial membrane and intracellular membrane of the nuclear envelope. |
| Background: | Bcl2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of Bcl2, such as in the case of translocation of Bcl2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C terminal ends. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| ListPrice: | 340 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Apoptosis regulator Bcl 2 antibody; Anti-Apoptosis regulator Bcl2 antibody; Anti-B cell CLL/lymphoma 2 antibody; Anti-B cell leukemia/lymphoma 2 antibody; Anti-B cell lymphoma 2 antibody; Anti-Bcl 2 antibody; Anti-Bcl2 antibody; Anti-BCL2 protein antibody |
| ProteinTarget: | Bcl-2 (N-TERMINAL) |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Zinkel, S. et al. (2006) BCL2 family in DNA damage and cell cycle control. Cell Death Differ. 13: 1351-1359. 2. Aster, J.C. and Logtine, J.A. (2002) Detection of BCL2 rearrangements in follicular lymphoma. Am. J. Pathol. 160: 759-763. |