| CatalogCode: | NB100-63088 |
| ProductName: | p27/kip1 Antibody |
| Product Description: | Rabbit Polyclonal anti-p27/kip1 |
| Clonality: | Polyclonal |
| Immunogen: | Full length human p27 protein |
| Specificity: | NB100-63088 detects p27, a member of the Kip/Cip family of proteins which is also known as p27kip1. p27 is a cyclin dependent kinase inhibitor (CKI) which controls G1/S phase transition in the cell cycle. p27 prevents cell cycle progression by inhibiting the activity of cyclin E-Cdk2 and cyclin D-Cdk4/6, thus preventing E2F activation and S phase progression. Low p27 levels and/or cytosolic mis-localisation have been associated with the development of lung, breast, colon, oesophagus, and prostate tumours. |
| CrossReactivity: | Human. Not yet tested in other species. |
| Packaging: | 0.05 ml Whole antisera Rabbit antisera. |
| Uses: | This antibody is useful for ELISA, immunoprecipitation, Western Blot |
| Localization: | Nuclear and cytoplasmic in quiescent cells |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| ListPrice: | 295 |
| AppSummary: | ELISA, IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-CDKN 1B antibody; Anti-CDKN 4 antibody; Anti-CDKN1B antibody; Anti-CDKN4 antibody; Anti-Cyclin Dependent Kinase Inhibitor 1B antibody; Anti-Cyclin dependent kinase inhibitor p27 antibody; Anti-KIP 1 antibody; Anti-KIP1 antibody; Anti-MEN1B antibody; Anti-p27 Kip1 antibody; Anti-P27KIP1 antibody |
| ProteinTarget: | p27/kip1 |
| PackageSize: | 0.05 ml |
| GeneralRef: | 1. Viglietto G, et al. (2002) Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization? Cell Cycle. 1: 394-400. 2. Musgrove, E.A. et al. (2004) Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice. J. Mammary Gland Biol. Neoplasia. 9: 55-66. 3. Kaldis P. (2007) Another piece of the p27Kip1 puzzle. Cell. 128: 241-244. |
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